For Burn patients, and in Reconstructive and Aesthetic Surgery where tissue approximation is critical to the healing process, ARTISS fibrin sealant provides advanced capabilities to adhere autologous skin grafts and skin flaps to wound beds in adult and paediatric populations. ARTISS is indicated as an adjunct to haemostasis on subcutaneous tissue surfaces. The unique properties of ARTISS enable freedom and precision in the operating room.
See Indications
Image of Artiss in applicator

Image of Artiss being applied to the wound on the side of a woman's face.

As the first and only fibrin sealant custom designed for tissue adherence in plastic, reconstructive and burn surgery, ARTISS is effective in a pivotal phase 3, multicenter, prospective, randomised, clinical study.1

Two images - one showing the application of Artiss and the other showing the graft application by hand

Mechanism of Action

ARTISS is a two component fibrin sealant, consisting of human thrombin and human fibrinogen and an antifibrinolytic inhibitor to delay clot degradation.2

Upon mixing, soluble fibrinogen is transformed into a fibrin matrix that adheres to the wound surface and to the skin graft to be affixed.2

Initial polymerisation of ARTISS will take up to 60 seconds due to optimised thrombin concentration; allowing time to manipulate and position the graft prior to polymerisation.2

The adhesive properties of ARTISS provide full surface adherence of the graft to the wound bed, closing the  space that exists when grafts are attached using point fixation techniques such as staples.1

ARTISS may reduce or eliminate the need for staple application or removal.1

Additional Product Benefits

Significantly Reduced Drainage Volume

In facial rhytidectomy, drainage volume was reduced on average by 62%, when evaluated 24 hours (+/- 4h) post-surgery, when ARTISS was used with the standard of care (SoC) vs. SoC alone (7.7 ± 7.4 mL vs 20.0 ± 11.3 mL (p < 0.0001), n=75). ARTISS may also eliminate the need for surgical drains.3

Effective for Complete Wound Closure

In burn surgeries, ARTISS has been demonstrated to be better than staples, with 43.3% of sites achieving full wound closure by day 28 compared to 37.0% for staples.2

Flexible and Convenient


ARTISS allows up to 60 seconds to manipulate and position the tissue flap. In addition, it doesn’t require any mixing or reconstitution, and it may be stored for up to 14 days at controlled room temperature (not exceeding +25°C) when unopened pouches are thawed at room temperature.3


Prescribing Information


Baxter takes safety of our products and patients very seriously. If you would like to report an adverse event with Baxter drugs (e.g. Tisseel, Artiss, …), you can contact Baxter directly: [email protected] or you can report it via authority’s website:

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Any medical device product quality complaints (including medical device adverse incidents) relating to Baxter products should be sent to EMEA SHS Complaints Intake [email protected]